Description

2-Bromo-n-Methyl-5-(Trifluoromethoxy)Aniline, Hcl is a specialized halogenated aniline derivative, serving as a critical building block in advanced organic synthesis. This compound matters for its unique trifluoromethoxy and bromo substituents, which are key for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of potential drug candidates, especially in central nervous system (CNS) and antiviral research.
• Agrochemical Development: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of advanced electronic materials and functional dyes.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex aromatic systems.
• Chemical Research & Development: Utilized in academic and industrial labs for exploring new chemical entities and reaction pathways.

Basic Information

Product Name	2-Bromo-n-Methyl-5-(Trifluoromethoxy)Aniline, Hcl
CAS No.	1215206-76-0
Molecular Formula	C9H8BrF3NO•HCl
Molecular Weight	322.53 g/mol (Free base: 286.07 g/mol)
Synonyms	2-Bromo-N-methyl-5-(trifluoromethoxy)aniline hydrochloride; 1-Bromo-2-(methylamino)-4-(trifluoromethoxy)benzene hydrochloride; 2-Bromo-5-(trifluoromethoxy)-N-methylaniline HCl; 2-Bromo-N-methyl-5-(trifluoromethoxy)benzenamine hydrochloride; Benzenamine, 2-bromo-N-methyl-5-(trifluoromethoxy)-, hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Bromo-n-Methyl-5-(Trifluoromethoxy)Aniline, Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.