Description

6-(Trifluoromethoxy)Quinoline Hcl is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound matters for its unique trifluoromethoxy-substituted quinoline scaffold, which is critical for modulating the biological activity, metabolic stability, and lipophilicity of target molecules. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the trifluoromethoxy group enhances bioactivity.
• Material Science: Serves as a precursor for creating functional organic materials, such as ligands for catalysts or components in organic electronics.
• Chemical Synthesis: Employed in cross-coupling reactions and as a versatile scaffold for constructing complex heterocyclic compounds in medicinal chemistry.
• Academic & Contract Research: Utilized in university and CRO laboratories for fundamental research and custom synthesis projects.

Basic Information

Product Name	6-(Trifluoromethoxy)Quinoline Hcl
CAS No.	1215206-34-0
Molecular Formula	C₁₀H₇F₃NO•HCl
Molecular Weight	249.62 g/mol (Free base: 213.17 g/mol)
Synonyms	6-(Trifluoromethoxy)quinoline hydrochloride; Quinoline, 6-(trifluoromethoxy)-, hydrochloride; 6-Trifluoromethoxyquinoline HCl; 6-(Trifluoromethoxy)quinoline HCl salt; 6-TFMQ HCl; 6-(Trifluoromethoxy)quinoline monohydrochloride
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethoxy)Quinoline Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.