Description

1-Bromo-2-(Methylsulfonyl)-4-(Trifluoromethyl)Benzene is a high-value, multi-functional aromatic building block designed for advanced chemical synthesis. Its unique structure, featuring bromine, methylsulfonyl, and trifluoromethyl substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology, where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity imparted by the halogen and sulfone functionalities.
• Ligand and Catalyst Development: Serves as a sophisticated building block for creating novel ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as semiconductors for OLEDs or OFETs, where the electron-withdrawing groups fine-tune HOMO/LUMO energy levels.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira, Buchwald-Hartwig) to form complex biaryl and other conjugated systems.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes and tags to study biological processes and protein interactions.

Basic Information

Item	Detail
Product Name	1-Bromo-2-(Methylsulfonyl)-4-(Trifluoromethyl)Benzene
CAS No.	1215205-98-3
Molecular Formula	C9H6BrF3O2S
Molecular Weight	315.11 g/mol
Synonyms	2-Bromo-1-(Methylsulfonyl)-4-(Trifluoromethyl)Benzene; 4-Bromo-3-(Methylsulfonyl)benzotrifluoride; 1-Bromo-2-(Methanesulfonyl)-4-(Trifluoromethyl)benzene; 2-Bromo-α,α,α-trifluoro-4-(methylsulfonyl)toluene; 4-(Trifluoromethyl)-2-(methylsulfonyl)bromobenzene; 2-(Methylsulfonyl)-4-(trifluoromethyl)bromobenzene
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-2-(Methylsulfonyl)-4-(Trifluoromethyl)Benzene is manufactured and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency to meet the rigorous demands of research and scale-up processes. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.