Description

1,1-Difluoro-5-Azaspiro[2.4]Heptane is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and azetidine scaffold. This compound is specifically engineered to serve as a critical building block in modern medicinal chemistry, enabling the synthesis of novel bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within drug discovery programs targeting central nervous system (CNS) disorders and other complex diseases.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Building Block: Used to introduce the constrained 5-azaspiro[2.4]heptane moiety into molecular frameworks to modulate physicochemical and pharmacokinetic properties.
• Drug Discovery & Development: Employed in high-throughput screening libraries and structure-activity relationship (SAR) studies for CNS-targeted and other therapeutic areas.
• Agrochemical Research: Potential application as a specialty intermediate in the development of new crop protection agents with novel modes of action.
• Material Science Research: Investigated for the synthesis of advanced polymers or ligands with specific electronic or steric properties.

Basic Information

Product Name	1,1-Difluoro-5-Azaspiro[2.4]Heptane
CAS No.	1215166-77-0
Molecular Formula	C7H9F2N
Molecular Weight	145.15 g/mol
Synonyms	5-Azaspiro[2.4]heptane, 1,1-difluoro-; 1,1-Difluoro-5-azaspiro[2.4]heptane; 1,1-Difluoroazetidine-3-spirocyclopropane; Difluoroazaspiroheptane; Azetidine, 1,1-difluoro-3-spirocyclopropane-; Spiro[cyclopropane-1,3'-azetidine], 1',1'-difluoro-
EINECS	Contact for details

Quality Control

Our 1,1-Difluoro-5-Azaspiro[2.4]Heptane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency essential for sensitive pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong acids. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.