Description

2-Amino-3-(4-Chloro-Phenyl)-3,3-Difluoro-Propionic Acid Hcl is a high-purity, non-natural amino acid derivative characterized by a difluoromethyl group and a chlorophenyl moiety. This compound serves as a critical pharmaceutical intermediate and building block for medicinal chemistry research, enabling the synthesis of novel bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, enzyme modulators, and other active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a specialized building block to introduce fluorine and chlorine atoms into target molecules, optimizing their pharmacokinetic and binding properties.
• Agrochemical Synthesis: Serves as a precursor in the research and development of advanced herbicides and pesticides with enhanced efficacy.
• Peptidomimetics: Incorporated into peptide analogs to improve metabolic stability and membrane permeability.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis projects.

Basic Information

Product Name	2-Amino-3-(4-Chloro-Phenyl)-3,3-Difluoro-Propionic Acid Hcl
CAS No.	1214699-21-4
Molecular Formula	C9H9ClF2NO2 • HCl
Molecular Weight	280.53 g/mol (Free base: 244.62 g/mol)
Synonyms	2-Amino-3-(4-chlorophenyl)-3,3-difluoropropanoic acid hydrochloride; 3,3-Difluoro-3-(4-chlorophenyl)alanine hydrochloride; (2R/S)-2-Amino-3-(4-chlorophenyl)-3,3-difluoropropionic acid hydrochloride; 4-Chloro-α,α-difluoro-DL-phenylglycine hydrochloride; DL-2-Amino-3-(4-chlorophenyl)-3,3-difluoropropanoic acid HCl; (RS)-2-Amino-3-(4-chlorophenyl)-3,3-difluoropropionic acid hydrochloride salt
EINECS	Contact for details

Quality Control

Our 2-Amino-3-(4-Chloro-Phenyl)-3,3-Difluoro-Propionic Acid Hcl is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and MS. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Chiral Purity (if applicable)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.