Description

(1S)-1-(3,4-Dimethoxyphenyl)-2,2,2-Trifluoroethylamine is a high-purity chiral amine building block of significant interest in advanced organic synthesis. Its value lies in its unique trifluoroethylamine moiety attached to a dimethoxyphenyl ring, which is crucial for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of new active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorine atoms enhance metabolic stability and bioavailability.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with tailored properties.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in regulated industries.

Basic Information

Product Name	(1S)-1-(3,4-Dimethoxyphenyl)-2,2,2-Trifluoroethylamine
CAS No.	1213893-62-9
Molecular Formula	C10H12F3NO2
Molecular Weight	235.20 g/mol
Synonyms	(S)-1-(3,4-Dimethoxyphenyl)-2,2,2-trifluoroethanamine; (S)-α-(Trifluoromethyl)-3,4-dimethoxybenzeneethanamine; (1S)-1-(3,4-Dimethoxyphenyl)-2,2,2-trifluoroethanamine; (S)-3,4-Dimethoxy-α-(trifluoromethyl)benzylamine; (S)-1-(3,4-Dimethoxyphenyl)-2,2,2-trifluoroethylamine; (S)-TFM-DMPA; (S)-Trifluoroethylamine-DMP derivative
EINECS	Contact for details

Quality Control

Our (1S)-1-(3,4-Dimethoxyphenyl)-2,2,2-Trifluoroethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting customer specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.