Description

(S)-2,2,2-Trifluoro-1-(2-Methoxyphenyl)Ethanamine Hydrochloride is a high-purity chiral amine building block, specifically the hydrochloride salt of the (S)-enantiomer. This compound is a critical intermediate in modern pharmaceutical synthesis, valued for its trifluoromethyl group and chiral center which impart unique biological activity and metabolic stability to drug candidates. It is primarily sought by R&D and process development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug discovery.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances lipophilicity and biological efficacy.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Research: Employed as a molecular probe or building block in medicinal chemistry for structure-activity relationship (SAR) studies.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes for commercial manufacturing under GMP guidelines.

Basic Information

Product Name	(S)-2,2,2-Trifluoro-1-(2-Methoxyphenyl)Ethanamine Hydrochloride
CAS No.	1213834-55-9
Molecular Formula	C9H11ClF3NO
Molecular Weight	241.64 g/mol
Synonyms	(S)-2,2,2-Trifluoro-1-(2-methoxyphenyl)ethan-1-amine hydrochloride; (S)-1-(2-Methoxyphenyl)-2,2,2-trifluoroethylamine hydrochloride; (S)-α-(Trifluoromethyl)-2-methoxybenzylamine hydrochloride; (S)-2-Methoxy-α-(trifluoromethyl)benzylamine hydrochloride; (S)-1-(2-Methoxyphenyl)-2,2,2-trifluoroethanamine HCl; (S)-TFMPA HCl; (S)-2,2,2-Trifluoro-1-(o-methoxyphenyl)ethylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2,2,2-Trifluoro-1-(2-Methoxyphenyl)Ethanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.