Description

(R)-1-[3-(Trifluoromethyl)Phenyl]Ethylamine-Hcl CAS NO 1213630-93-3 is a high-purity chiral amine building block, specifically the hydrochloride salt of the (R)-enantiomer. This compound is a critical intermediate in the synthesis of advanced pharmaceutical active ingredients and agrochemicals, where its defined stereochemistry is essential for biological activity. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and fine chemical producers engaged in the development of novel therapeutics and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) drugs and other therapeutic agents requiring specific enantiomeric purity.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the (R)-configuration imparts desired biological selectivity and efficacy.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce stereoselectivity in chemical reactions.
• Research & Development: Employed in medicinal chemistry and process chemistry R&D for exploring new chemical entities and optimizing synthetic routes.
• Fine Chemical Production: A valuable building block for manufacturing complex, high-value specialty chemicals beyond the life sciences sector.

Basic Information

Product Name	(R)-1-[3-(Trifluoromethyl)Phenyl]Ethylamine Hydrochloride
CAS No.	1213630-93-3
Molecular Formula	C9H11F3N • HCl
Molecular Weight	225.65 g/mol (Free base: 189.19 g/mol)
Synonyms	(R)-1-[3-(Trifluoromethyl)phenyl]ethanamine hydrochloride; (R)-α-Methyl-3-(trifluoromethyl)benzylamine hydrochloride; (R)-1-(3-Trifluoromethylphenyl)ethylamine HCl; (R)-3'-(Trifluoromethyl)phenethylamine hydrochloride; (R)-1-(3-(Trifluoromethyl)phenyl)ethan-1-amine hydrochloride; (R)-TFMPEA HCl; (R)-1-(m-Trifluoromethylphenyl)ethylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-1-[3-(Trifluoromethyl)Phenyl]Ethylamine-Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for pharmaceutical development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider using a desiccator or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.