Description

(S)-4-(Pyrrolidin-2-Yl)Benzoic Acid is a high-purity chiral building block featuring a benzoic acid moiety linked to a (S)-pyrrolidine ring. This specific stereochemistry is critical for its role in the research and development of novel pharmaceutical compounds, particularly those targeting the central nervous system. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential therapeutic agents, including receptor modulators and enzyme inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Asymmetric Synthesis: Serves as a versatile building block for constructing complex molecules with defined stereocenters.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development and quality control in API manufacturing.
• Ligand Precursor: Can be utilized in the development of chiral ligands for catalysis.
• Bioconjugation Chemistry: The carboxylic acid group allows for coupling to biomolecules or other chemical entities.

Basic Information

Product Name	(S)-4-(Pyrrolidin-2-Yl)Benzoic Acid
CAS No.	1213448-39-5
Molecular Formula	C11H13NO2
Molecular Weight	191.23 g/mol
Synonyms	(S)-4-(2-Pyrrolidinyl)benzoic acid; (S)-2-(4-Carboxyphenyl)pyrrolidine; 4-[(2S)-Pyrrolidin-2-yl]benzoic acid; Benzoic acid, 4-[(2S)-2-pyrrolidinyl]-; (S)-4-Pyrrolidin-2-yl-benzoic acid; (S)-2-(4-Carboxy-phenyl)-pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-4-(Pyrrolidin-2-Yl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.