Description

4-((1R)-1-Aminoethyl)-3-Chlorophenol is a chiral, multifunctional phenolic compound that serves as a critical intermediate in advanced organic synthesis. Its unique structure, featuring both a phenolic hydroxyl group and a chiral aminoethyl side chain, makes it a valuable building block for creating complex, optically active molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical sectors, where it is used to synthesize novel active ingredients with specific stereochemical requirements.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides where stereochemistry influences biological activity and environmental safety.
• Ligand and Catalyst Development: Precursor for synthesizing chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Intermediate in the production of specialty polymers and advanced organic materials with tailored properties.
• Bioconjugation Chemistry: Useful in modifying biomolecules due to its reactive phenolic and amine functional groups.
• Academic and R&D Laboratories: Serves as a reference standard and starting material for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	4-((1R)-1-Aminoethyl)-3-Chlorophenol
CAS No.	1213373-53-5
Molecular Formula	C8H10ClNO
Molecular Weight	171.62 g/mol
Synonyms	(R)-1-(3-Chloro-4-hydroxyphenyl)ethan-1-amine; (1R)-1-(3-Chloro-4-hydroxyphenyl)ethylamine; 3-Chloro-4-[(1R)-1-aminoethyl]phenol; 4-[(1R)-1-Aminoethyl]-3-chlorophenol; (R)-3-Chloro-4-(1-aminoethyl)phenol; (R)-1-(4-Hydroxy-3-chlorophenyl)ethylamine; (R)-α-Methyl-3-chloro-4-hydroxybenzylamine
EINECS	Contact for details

Quality Control

Our 4-((1R)-1-Aminoethyl)-3-Chlorophenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure it meets the high standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity (HPLC), enantiomeric excess, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.