Description

[4-((2R)Pyrrolidin-2-Yl)Phenoxy]Trifluoromethane is a chiral, fluorinated organic building block of significant interest in advanced pharmaceutical and agrochemical research. Its core value lies in the unique combination of a stereodefined pyrrolidine moiety and a trifluoromethoxy group, enabling the modulation of biological activity, metabolic stability, and physicochemical properties in lead compounds. This high-purity intermediate is essential for medicinal chemists and R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in developing advanced pesticides and herbicides where the trifluoromethoxy group enhances lipophilicity and biological activity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands in asymmetric catalysis and organocatalysis.
• Material Science: Potential building block for specialty polymers and liquid crystals due to its aromatic and fluorinated structure.
• Chemical Biology Probes: Utilized in creating molecular probes for studying enzyme mechanisms and protein-ligand interactions.

Basic Information

Item	Details
Product Name	[4-((2R)Pyrrolidin-2-Yl)Phenoxy]Trifluoromethane
CAS No.	1213312-86-7
Molecular Formula	C11H12F3NO
Molecular Weight	231.21 g/mol
Synonyms	(R)-4-(2-Pyrrolidinyl)phenoxytrifluoromethane; (2R)-2-[4-(Trifluoromethoxy)phenyl]pyrrolidine; 4-[(2R)-Pyrrolidin-2-yl]phenyl trifluoromethyl ether; 4-((R)-Pyrrolidin-2-yl)phenoxytrifluoromethane; CAS 1213312-86-7
EINECS	Contact for details

Quality Control

Our [4-((2R)Pyrrolidin-2-Yl)Phenoxy]Trifluoromethane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.