Description

(2R)-2-Amino-2-(5-Fluoro-2-Hydroxyphenyl)Acetic Acid Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its value lies in its defined stereochemistry and functional groups, which are critical for synthesizing active pharmaceutical ingredients (APIs) with specific biological activity. This compound is essential for research and development chemists and manufacturers in the pharmaceutical and fine chemical industries, particularly those focused on developing novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder therapies.
• API Synthesis: Serves as a critical building block in multi-step synthetic routes for Active Pharmaceutical Ingredients (APIs) requiring a fluorinated phenylglycine moiety.
• Peptidomimetics Research: Used in the design and synthesis of peptidomimetics and constrained amino acid analogs for medicinal chemistry programs.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in asymmetric synthesis to induce chirality in target molecules.
• Biochemical Research: Utilized as a standard or reagent in biochemical studies investigating enzyme mechanisms or receptor binding.
• Fine Chemical Production: Incorporated into the manufacture of advanced fine chemicals and specialty materials where high stereochemical purity is required.

Basic Information

Item	Detail
Product Name	(2R)-2-Amino-2-(5-Fluoro-2-Hydroxyphenyl)Acetic Acid Hydrochloride
CAS No.	1212934-96-7
Molecular Formula	C8H9FNO3 • HCl
Molecular Weight	235.62 g/mol (Free base: 199.16 g/mol)
Synonyms	(R)-2-Amino-2-(5-Fluoro-2-hydroxyphenyl)acetic acid hydrochloride; (2R)-2-Amino-2-(5-Fluoro-2-hydroxyphenyl)ethanoic acid hydrochloride; D-5-Fluoro-2-hydroxyphenylglycine hydrochloride; (R)-5-Fluoro-2-hydroxyphenylglycine HCl; (R)-2-Amino-2-(5-Fluoro-2-hydroxy-phenyl)acetic acid hydrochloride; 5-Fluoro-D-2-hydroxyphenylglycine hydrochloride; (R)-(-)-2-Amino-2-(5-Fluoro-2-hydroxyphenyl)acetic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (2R)-2-Amino-2-(5-Fluoro-2-Hydroxyphenyl)Acetic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.