Description

Ethyl (R)-3-Amino-4,4,4-Trifluorobutanoate Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is valued for its trifluoromethyl group and chiral amino acid ester structure, which are critical for modulating the biological activity and metabolic stability of advanced drug candidates. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in medicinal chemistry and process research.

Application

• Key chiral intermediate in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Building block for medicinal chemistry research, enabling the exploration of structure-activity relationships (SAR).
• Precursor for the development of fluorinated amino acid derivatives and peptidomimetics.
• Used in process chemistry for route scouting and scale-up of complex organic molecules.
• Starting material for the synthesis of specialized ligands and catalysts in asymmetric synthesis.
• Research chemical for biochemical studies and proteomics.

Basic Information

Product Name	Ethyl (R)-3-Amino-4,4,4-Trifluorobutanoate Hydrochloride
CAS No.	1212365-10-0
Molecular Formula	C6H11ClF3NO2
Molecular Weight	221.60 g/mol
Synonyms	(R)-Ethyl 3-Amino-4,4,4-trifluorobutanoate Hydrochloride; Ethyl (3R)-3-Amino-4,4,4-trifluorobutanoate Hydrochloride; (R)-3-Amino-4,4,4-trifluorobutyric Acid Ethyl Ester Hydrochloride; (R)-ATFB-OEt HCl; (R)-3-ATB-OEt HCl; (R)-Ethyl 4,4,4-trifluoro-3-aminobutanoate Hydrochloride; (R)-3-Amino-4,4,4-trifluorobutanoic Acid Ethyl Ester Hydrochloride
EINECS	Contact for details

Quality Control

Our Ethyl (R)-3-Amino-4,4,4-Trifluorobutanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.