Description

α-Me-D-Phe(3-Br)-Oh·H2O is a non-natural, brominated amino acid derivative, specifically a modified D-phenylalanine. This compound is a high-value building block in advanced pharmaceutical research and development, prized for its role in creating novel peptide-based therapeutics and diagnostic agents. It is primarily utilized by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in peptide synthesis, medicinal chemistry, and the development of enzyme inhibitors or receptor ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex peptide drugs and bioactive molecules.
• Medicinal Chemistry Research: Used to study structure-activity relationships (SAR) and develop enzyme inhibitors or receptor modulators.
• Peptide Synthesis: Incorporated into custom peptides to confer specific properties like metabolic stability, altered binding affinity, or as a spectroscopic probe.
• Bioconjugation & Probe Development: The bromine atom serves as a handle for further chemical modifications, such as in the creation of fluorescent or affinity labels.
• Academic & Industrial R&D: Employed in exploratory research for new therapeutic targets in oncology, neurology, and metabolic diseases.

Basic Information

Product Name	α-Me-D-Phe(3-Br)-Oh·H2O
CAS No.	1212321-90-8
Molecular Formula	C10H12BrNO3·H2O
Molecular Weight	288.12 g/mol (Anhydrous basis: 270.11)
Synonyms	(R)-2-Amino-3-(3-bromophenyl)-2-methylpropanoic acid hydrate; D-3-Bromo-α-methylphenylalanine hydrate; (R)-α-Methyl-3-bromo-D-phenylalanine monohydrate; (2R)-2-Amino-2-methyl-3-(3-bromophenyl)propanoic acid hydrate; Boc-D-Phe(3-Br)-α-Me-OH precursor; Non-natural brominated amino acid derivative
EINECS	Contact for details

Quality Control

Every batch of α-Me-D-Phe(3-Br)-Oh·H2O is manufactured and tested under strict quality management systems. We provide comprehensive analytical data including HPLC purity, chiral purity, and identity confirmation to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatograms and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de (D-isomer)
Water Content (KF)	5.0% - 7.5% (Theoretical for monohydrate: ~6.25%)
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.