Description

(1R)-1-(2-Chloro-4-Fluorophenyl)Ethan-1-Amine is a high-purity chiral amine building block of significant importance in modern pharmaceutical synthesis. This compound serves as a critical intermediate for the development of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the discovery and production of novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Used as a building block for constructing complex molecules with defined stereochemistry in medicinal chemistry.
• Agrochemical Research: Potential intermediate in the development of advanced pesticides and herbicides.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Academic & Industrial R&D: Employed in chemical research for studying structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	(1R)-1-(2-Chloro-4-Fluorophenyl)Ethan-1-Amine
CAS No.	1212201-70-1
Molecular Formula	C8H9ClFN
Molecular Weight	173.61 g/mol
Synonyms	(1R)-1-(2-Chloro-4-fluorophenyl)ethanamine; (R)-1-(2-Chloro-4-fluorophenyl)ethylamine; (R)-2-Chloro-4-fluoro-α-methylbenzylamine; (R)-1-Amino-1-(2-chloro-4-fluorophenyl)ethane; (R)-α-Methyl-2-chloro-4-fluorobenzylamine; (R)-1-(2-Chloro-4-fluorophenyl)ethan-1-amine; (R)-1-(2-Chloro-4-fluorophenyl)ethylamine hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our (1R)-1-(2-Chloro-4-Fluorophenyl)Ethan-1-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Products undergo rigorous analytical testing, including chiral HPLC to confirm enantiomeric excess (ee). A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.