Description

(2S,4S)-4-Fmoc-Amino Pyrrolidine-2-Carboxylic Acid Methylester-Hcl is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex peptide structures with defined stereochemistry. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers developing peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected proline analog for the automated synthesis of therapeutic peptides.
• Peptidomimetic Drug Development: For creating constrained peptide scaffolds and mimetics with enhanced metabolic stability and bioavailability.
• Combinatorial Chemistry Libraries: As a versatile chiral scaffold for generating diverse compound libraries in drug discovery campaigns.
• Bioconjugation & Probe Synthesis: In the preparation of labeled peptides for biochemical assays, imaging, and diagnostic applications.
• Academic & Industrial Research: For fundamental studies in organic chemistry, medicinal chemistry, and chemical biology.
• Custom Peptide Service Providers: As a high-quality raw material for producing custom peptides for clients worldwide.

Basic Information

Product Name	(2S,4S)-4-Fmoc-Amino Pyrrolidine-2-Carboxylic Acid Methylester Hydrochloride
CAS No.	1212153-95-1
Molecular Formula	C22H25N2O5 • HCl
Molecular Weight	448.91 g/mol (as free base)
Synonyms	(2S,4S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-aminopyrrolidine-2-carboxylic acid methyl ester hydrochloride; Fmoc-(2S,4S)-4-Amino-pyrrolidine-2-carboxylic acid methyl ester HCl; Methyl (2S,4S)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}pyrrolidine-2-carboxylate hydrochloride; (2S,4S)-4-[(Fmoc)amino]pyrrolidine-2-carboxylic acid methyl ester hydrochloride; Fmoc-Aze(4-NH2)-OMe • HCl; Fmoc-cis-4-Aminoproline-OMe hydrochloride
EINECS	Contact for details

Quality Control

Our (2S,4S)-4-Fmoc-Amino Pyrrolidine-2-Carboxylic Acid Methylester-Hcl is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards and can provide material with specifications tailored to your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.