Description

(R)-1,1,1-Trifluoro-2-Butylamine Hydrochloride CAS NO 1212120-62-1 is a high-purity chiral amine hydrochloride salt, characterized by its trifluoromethyl group, which imparts unique physicochemical properties critical for advanced synthesis. This compound serves as a versatile and valuable chiral building block in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its stereochemistry and fluorine content are essential for modulating biological activity and metabolic stability. It is primarily targeted at research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors engaged in the synthesis of fluorinated bioactive molecules.

Application

• As a key chiral intermediate in the asymmetric synthesis of pharmaceutical candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Utilized in the research and development of fluorinated agrochemicals, such as herbicides and fungicides, where the trifluoromethyl group enhances lipophilicity and environmental stability.
• Employed in the preparation of ligands and catalysts for asymmetric catalysis, enabling the synthesis of enantiomerically pure compounds.
• Serves as a precursor for the synthesis of advanced materials and specialty polymers where fluorine incorporation is desired for specific thermal or chemical resistance properties.
• Used in academic and industrial R&D for exploring structure-activity relationships (SAR) in medicinal chemistry programs focused on fluorinated analogs.

Basic Information

Product Name	(R)-1,1,1-Trifluoro-2-Butylamine Hydrochloride
CAS No.	1212120-62-1
Molecular Formula	C₄H₈F₃N•HCl
Molecular Weight	175.57 g/mol
Synonyms	(R)-1,1,1-Trifluoro-2-aminobutane Hydrochloride; (R)-2-Amino-1,1,1-trifluorobutane Hydrochloride; (R)-1,1,1-Trifluoro-sec-butylamine Hydrochloride; (R)-α-Methyl-β,β,β-trifluoroethylamine Hydrochloride; (R)-CF3CH(NH2)CH2CH3•HCl; (R)-Trifluoro-2-butylamine HCl; (R)-TFA-Butylamine Hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-1,1,1-Trifluoro-2-Butylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with stringent pharmaceutical and research-grade standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.