Description

Methyl (3R,4R)-4-(Trifluoromethyl)Pyrrolidine-3-Carboxylate Hydrochloride is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial importance. Its value lies in its defined stereochemistry and the versatile trifluoromethylated pyrrolidine scaffold, which is crucial for modulating the pharmacokinetic and metabolic properties of bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients targeting the central nervous system, metabolic disorders, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel Active Pharmaceutical Ingredients (APIs), especially in CNS and metabolic disease research.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and stability.
• Medicinal Chemistry Research: Serves as a critical scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Peptidomimetics Development: Incorporated into peptide analogs to improve metabolic stability and membrane permeability.
• Ligand and Catalyst Preparation: Utilized in the synthesis of chiral ligands for asymmetric catalysis.
• Chemical Biology Probes: Acts as a building block for creating molecular probes to study biological pathways and enzyme function.

Basic Information

Product Name	Methyl (3R,4R)-4-(Trifluoromethyl)Pyrrolidine-3-Carboxylate Hydrochloride
CAS No.	1212115-75-7
Molecular Formula	C8H11F3NO2 • HCl
Molecular Weight	249.63 g/mol (Free base: 213.17 g/mol)
Synonyms	(3R,4R)-Methyl 4-(trifluoromethyl)-3-pyrrolidinecarboxylate hydrochloride; Methyl (3R,4R)-4-(trifluoromethyl)pyrrolidine-3-carboxylate HCl; (3R,4R)-1,2,5,6-Tetrahydropyridine-3-carboxylic acid, 4-(trifluoromethyl)-, methyl ester, hydrochloride; (3R,4R)-4-(Trifluoromethyl)pyrrolidine-3-carboxylic acid methyl ester hydrochloride; (3R,4R)-Methyl 4-(trifluoromethyl)pyrrolidine-3-carboxylate hydrochloride salt
EINECS	Contact for details

Quality Control

Our Methyl (3R,4R)-4-(Trifluoromethyl)Pyrrolidine-3-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing chiral purity, assay, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.