Description

4-Bromo-3-Chloro-6-Trifluoromethoxyquinoline is a high-purity, multi-functional halogenated quinoline derivative, serving as a critical advanced intermediate in modern organic synthesis. Its unique trifluoromethoxy and halogen substitution pattern makes it a valuable scaffold for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel agrochemicals, pharmaceuticals, and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically active heterocycles.
• Agrochemical Research: Used in the development of next-generation pesticides and herbicides, where the quinoline core and halogen atoms contribute to bioactivity and environmental stability.
• Material Science Precursor: Serves as a precursor for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Chemical Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to introduce complex quinoline motifs.
• Fluorine Chemistry Studies: The trifluoromethoxy group makes it a valuable compound for research in fluorine chemistry and the study of its effects on molecular properties.

Basic Information

Item	Details
Product Name	4-Bromo-3-Chloro-6-Trifluoromethoxyquinoline
CAS No.	1211818-09-5
Molecular Formula	C₁₀H₄BrClF₃NO
Molecular Weight	326.50 g/mol
Synonyms	4-Bromo-3-chloro-6-(trifluoromethoxy)quinoline; 6-(Trifluoromethoxy)-4-bromo-3-chloroquinoline; 4-Bromo-3-chloro-6-trifluoromethoxy-quinoline; Quinoline, 4-bromo-3-chloro-6-(trifluoromethoxy)-; 1211818-09-5
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Chloro-6-Trifluoromethoxyquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to traceability and documentation supports your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.