Description

4-Bromo-3-Chloro-8-Fluoroquinoline is a high-purity, multi-halogenated quinoline derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it a versatile and valuable intermediate for constructing complex molecular architectures. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel fluoroquinolone antibiotics and other bioactive molecules targeting bacterial infections.
• Agrochemical Research: Used in the development of next-generation herbicides and pesticides, leveraging the halogenated quinoline scaffold for enhanced activity.
• Material Science: Serves as a building block for creating organic semiconductors, liquid crystals, and fluorescent dyes due to its electron-deficient aromatic system.
• Chemical Synthesis: A versatile reagent for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution, enabling complex molecule assembly.
• Academic & R&D: Essential for medicinal chemistry programs exploring structure-activity relationships (SAR) and for synthesizing compound libraries for high-throughput screening.

Basic Information

Product Name	4-Bromo-3-Chloro-8-Fluoroquinoline
CAS No.	1211659-63-0
Molecular Formula	C9H4BrClFN
Molecular Weight	260.49 g/mol
Synonyms	8-Fluoro-4-bromo-3-chloroquinoline; 3-Chloro-4-bromo-8-fluoroquinoline; Quinoline, 4-bromo-3-chloro-8-fluoro-; 4-Bromo-3-chloro-8-fluoro-quinoline; 1211659-63-0; 8-Fluoro-3-chloro-4-bromoquinoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Chloro-8-Fluoroquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.