Description

3,4,5,6-Tetrahydro-5-Oxo-2,6-Naphthyridine-2(1H)-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its naphthyridine core structure. This compound is of significant value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic chemistry. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel drug candidates, where consistent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• API Synthesis: Serves as a key scaffold for constructing the core structure of potential new chemical entities (NCEs) during drug discovery and development phases.
• Medicinal Chemistry Research: Used in research laboratories for structure-activity relationship (SAR) studies and lead optimization processes to enhance drug efficacy and safety profiles.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.
• Chemical Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	3,4,5,6-Tetrahydro-5-Oxo-2,6-Naphthyridine-2(1H)-Carboxylic Acid tert-Butyl Ester
CAS No.	1211594-91-0
Molecular Formula	C₁₃H₁₈N₂O₃
Molecular Weight	250.30 g/mol
Synonyms	tert-Butyl 3,4,5,6-tetrahydro-5-oxo-2,6-naphthyridine-2(1H)-carboxylate; 2,6-Naphthyridine-2(1H)-carboxylic acid, 3,4,5,6-tetrahydro-5-oxo-, 1,1-dimethylethyl ester; 2-(tert-Butoxycarbonyl)-3,4,5,6-tetrahydro-2,6-naphthyridin-5-one; 2-Boc-3,4,5,6-tetrahydro-2,6-naphthyridin-5-one; 5-Oxo-3,4,5,6-tetrahydro-2,6-naphthyridine-2(1H)-carboxylic acid tert-butyl ester; Boc-protected tetrahydronaphthyridinone
EINECS	Contact for details

Quality Control

Our 3,4,5,6-Tetrahydro-5-Oxo-2,6-Naphthyridine-2(1H)-Carboxylic Acid tert-Butyl Ester is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the exacting standards required for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support compliance with ICH guidelines and relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.