Description

5-(Trifluoromethyl)-2,3-Dihydrospiro[Indene-1,2'-Pyrrolidine] is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and trifluoromethylated structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting the central nervous system and other therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate fluorine and constrained ring systems into new chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its spirocyclic scaffold and fluorine atom.
• Protease Inhibitor Development: The pyrrolidine moiety makes it a candidate for developing inhibitors of various enzymes.
• Ligand Synthesis for Catalysis: Can be utilized to create novel chiral ligands for asymmetric synthesis.
• Agrochemical Research: Serves as an intermediate in the development of new active ingredients with improved properties.
• Material Science Precursor: Potential use in creating specialty polymers or organic electronic materials with unique properties.

Basic Information

Product Name	5-(Trifluoromethyl)-2,3-Dihydrospiro[Indene-1,2'-Pyrrolidine]
CAS No.	1211594-38-5
Molecular Formula	C14H14F3N
Molecular Weight	253.26 g/mol
Synonyms	2,3-Dihydrospiro[indene-1,2'-pyrrolidine], 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-2,3-dihydro-1H-spiro[indene-1,2'-pyrrolidine]; 1'H-Spiro[indene-1,2'-pyrrolidine], 2,3-dihydro-5-(trifluoromethyl)-; 5-(Trifluoromethyl)spiro[indane-1,2'-pyrrolidine]; Spiro[indane-1,2'-pyrrolidine], 5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-2,3-Dihydrospiro[Indene-1,2'-Pyrrolidine] is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.