Description

8-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine is a high-purity, advanced pharmaceutical intermediate featuring a unique fused heterocyclic structure. This compound is of significant commercial interest due to its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, especially within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug molecules, particularly those targeting the central nervous system (CNS) and oncology.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of target APIs under current Good Manufacturing Practice (cGMP) conditions.
• Agrochemical Synthesis: Potential intermediate in the development of novel herbicides and pesticides with enhanced efficacy.
• Material Science: Investigated as a precursor for specialty chemicals and functional materials due to its fluorine-containing moiety.

Basic Information

Product Name	8-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine
CAS No.	1211585-17-9
Molecular Formula	C11H13F3N2
Molecular Weight	230.23 g/mol
Synonyms	8-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,6]naphthyridine; 5,6,7,8-Tetrahydro-8-methyl-3-(trifluoromethyl)-1,6-naphthyridine; 1211585-17-9; 8-Methyl-3-trifluoromethyl-5,6,7,8-tetrahydro-1,6-naphthyridine; Tetrahydro-8-methyl-3-(trifluoromethyl)-1,6-naphthyridine
EINECS	Contact for details

Quality Control

Our production of 8-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine adheres to stringent quality management systems to ensure batch-to-batch consistency and purity. All material is subjected to rigorous analytical testing, including HPLC, GC, NMR, and MS, to confirm identity and meet specified impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We support development and commercial projects with material produced under quality standards appropriate for the intended use, from laboratory to cGMP grade.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.