Description

1H-Indazole,4-Bromo-3-(Trifluoromethyl)- is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a bromo substituent and a trifluoromethyl group on the indazole scaffold, enabling precise molecular modifications. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and oncology research programs.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the indazole core and fluorine atoms.
• Material Science: Serves as a precursor for advanced organic electronic materials and liquid crystals due to its rigid, planar structure and halogen/fluorine functionalities.
• Chemical Biology: Employed as a molecular probe or tag in bioconjugation and proteomics studies.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Functional Group Transformation: Used to introduce the valuable trifluoromethyl group into more complex molecular architectures.

Basic Information

Product Name	1H-Indazole,4-Bromo-3-(Trifluoromethyl)-
CAS No.	1211583-69-5
Molecular Formula	C8H4BrF3N2
Molecular Weight	265.03 g/mol
Synonyms	4-Bromo-3-(trifluoromethyl)-1H-indazole; 4-Bromo-3-(trifluoromethyl)indazole; 3-Trifluoromethyl-4-bromo-1H-indazole; 1H-Indazole, 4-bromo-3-(trifluoromethyl)-; 4-Bromo-3-trifluoromethylindazole; 4-Bromo-3-trifluoromethyl-1H-indazole; 1211583-69-5
EINECS	Contact for details

Quality Control

Our 1H-Indazole,4-Bromo-3-(Trifluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.