Description

tert-Butyl 2-Chloro-5,6-Dihydro-1,7-Naphthyridine-7(8H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key synthetic building block, enabling the efficient construction of complex nitrogen-containing heterocycles found in active pharmaceutical ingredients. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutic agents, particularly in oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those containing the 1,7-naphthyridine scaffold.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new small molecule therapeutics.
• Oncology Drug Development: Serves as a building block for kinase inhibitors and other targeted cancer therapies under investigation.
• CNS-Active Compound Synthesis: Employed in the research and development of potential treatments for neurological disorders.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Used in university and institutional labs for methodological studies in organic and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 2-Chloro-5,6-Dihydro-1,7-Naphthyridine-7(8H)-Carboxylate
CAS No.	1211581-54-2
Molecular Formula	C13H17ClN2O2
Molecular Weight	268.74 g/mol
Synonyms	7-Boc-2-chloro-5,6,7,8-tetrahydro-1,7-naphthyridine; tert-Butyl 2-chloro-5,6,7,8-tetrahydro-1,7-naphthyridine-7-carboxylate; 2-Chloro-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxylic acid tert-butyl ester; 2-Chloro-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,7-naphthyridine; Boc-2-chloro-1,7-naphthyridine; 1211581-54-2
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Chloro-5,6-Dihydro-1,7-Naphthyridine-7(8H)-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.