Description

6-(Difluoromethoxy)Nicotinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoromethoxy-substituted pyridine structure. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modifications. It is primarily sought after by research institutions, custom synthesis organizations, and pharmaceutical manufacturers engaged in the development of next-generation small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting metabolic and inflammatory pathways.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, leveraging the stability imparted by the difluoromethoxy group.
• Ligand and Catalyst Development: Serves as a functionalized starting material for creating specialized ligands in organometallic chemistry and catalysis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological mechanisms.
• Material Science: Investigated as a monomer or additive for creating specialty polymers with unique electronic or surface properties.

Basic Information

Product Name	6-(Difluoromethoxy)Nicotinic Acid
CAS No.	1211535-62-4
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	6-(Difluoromethoxy)pyridine-3-carboxylic acid; Nicotinic acid, 6-(difluoromethoxy)-; 3-Pyridinecarboxylic acid, 6-(difluoromethoxy)-; 6-Difluoromethoxynicotinic acid
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethoxy)Nicotinic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent control of residual solvents and impurities. We provide full traceability and detailed Certificates of Analysis (COA) to support your regulatory and R&D requirements, ensuring consistency and reliability for your critical synthesis processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.