Description

3,4-Dibromo-8-Trifluoromethylquinoline is a high-value, multi-functional halogenated quinoline derivative. This compound serves as a critical synthetic intermediate, prized for its unique molecular architecture that combines bromine substituents with a trifluoromethyl group. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the development of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Research: Used in the development of new-generation pesticides, herbicides, and fungicides, leveraging the bioactivity of the quinoline core and halogen atoms.
• Material Science Precursor: Serves as a starting material for creating organic semiconductors, liquid crystals, and fluorescent dyes due to its electron-deficient quinoline structure.
• Cross-Coupling Reactions: The bromine atoms act as excellent handles for palladium-catalyzed reactions (e.g., Suzuki, Negishi, Stille) to introduce complex substituents.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a molecular scaffold for probe development.
• Organic Synthesis: A versatile reagent for introducing the 8-trifluoromethylquinoline motif, a privileged structure in medicinal chemistry, into target molecules.

Basic Information

Product Name	3,4-Dibromo-8-Trifluoromethylquinoline
CAS No.	1210675-80-1
Molecular Formula	C10H4Br2F3N
Molecular Weight	354.95 g/mol
Synonyms	8-Trifluoromethyl-3,4-dibromoquinoline; 3,4-Dibromo-8-(trifluoromethyl)quinoline; Quinoline, 3,4-dibromo-8-(trifluoromethyl)-; 3,4-Dibrom-8-trifluormethylchinolin (German); 3,4-ジブロモ-8-トリフルオロメチルキノリン (Japanese); 3,4-二溴-8-三氟甲基喹啉 (Chinese)
EINECS	Contact for details

Quality Control

Every batch of 3,4-Dibromo-8-Trifluoromethylquinoline is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high purity and batch-to-batch consistency suitable for demanding research and scale-up applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles via techniques including HPLC, NMR, and GC-MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.