Description

6-Fluoro-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with significant synthetic utility. This compound is valued for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in innovative drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex drug candidates, especially those targeting neurological disorders.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing benzoxazine-based scaffolds with potential biological activity.
• Research & Development (R&D): Essential for academic and industrial research programs focused on heterocyclic chemistry and new therapeutic agents.
• Process Chemistry & Scale-Up: Serves as a starting material for optimizing synthetic routes and scaling up production for clinical trial materials.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	6-Fluoro-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine Hydrochloride
CAS No.	1210247-51-0
Molecular Formula	C8H9ClFNO
Molecular Weight	189.61 g/mol
Synonyms	6-Fluoro-3,4-dihydro-2H-1,4-benzoxazine hydrochloride; 2H-1,4-Benzoxazine, 6-fluoro-3,4-dihydro-, hydrochloride; 6-Fluoro-2H-1,4-benzoxazine-3(4H)-one hydrochloride (tautomer consideration); 6-Fluorodihydrobenzoxazine HCl; 1210247-51-0; 6-Fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine HCl
EINECS	Contact for details

Quality Control

Our 6-Fluoro-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.