Description

4-Amino-8-Bromo-3-Chloroquinoline is a high-purity, multi-functional halogenated quinoline derivative serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring distinct amino, bromo, and chloro substituents, makes it an exceptionally versatile intermediate for constructing complex heterocyclic systems. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinoline-based drug candidates, particularly for antimicrobial, anticancer, and anti-inflammatory applications.
• Agrochemical Research: Used in developing new generations of fungicides and herbicides, leveraging the bioactivity of the quinoline core.
• Material Science: Serves as a monomer or functionalizing agent in the creation of organic semiconductors, ligands for metal-organic frameworks (MOFs), and advanced polymers.
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination, Suzuki reactions) due to the reactive bromo and chloro handles.
• Dye & Pigment Industry: Acts as a starting material for synthesizing specialized heterocyclic dyes and fluorescent markers.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry and for exploring new reaction pathways.

Basic Information

Product Name	4-Amino-8-Bromo-3-Chloroquinoline
CAS No.	1210225-73-2
Molecular Formula	C9H6BrClN2
Molecular Weight	257.51 g/mol
Synonyms	8-Bromo-3-chloro-4-aminoquinoline; 3-Chloro-8-bromo-4-quinolinamine; 4-Quinolinamine, 8-bromo-3-chloro-; 4-Amino-8-bromo-3-chloroquinoline; 1210225-73-2; 8-Bromo-3-chloro-quinolin-4-ylamine; 3-Chloro-8-bromoquinolin-4-amine
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-8-Bromo-3-Chloroquinoline is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC-MS, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.