Description

4-Amino-6-Bromo-2-(Trifluoromethyl)Quinoline-3-Carbonitrile is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. Its core value lies in its unique molecular architecture, which combines a quinoline scaffold with bromo, amino, trifluoromethyl, and cyano functional groups, enabling precise molecular modifications. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a critical intermediate for developing novel active ingredients, particularly in medicinal chemistry for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially for kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the biological activity of the quinoline core and halogen substituents.
• Material Science: Serves as a building block for creating advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Synthesis: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitutions due to the reactive bromo and amino groups.
• Fluorine Chemistry: The trifluoromethyl group makes it a valuable synthon for introducing fluorine atoms into target molecules to enhance metabolic stability, lipophilicity, and bioavailability.
• Dye and Pigment Intermediate: Acts as a precursor for synthesizing specialized quinoline-based dyes and fluorescent markers.

Basic Information

Product Name	4-Amino-6-Bromo-2-(Trifluoromethyl)Quinoline-3-Carbonitrile
CAS No.	1209063-53-5
Molecular Formula	C₁₁H₅BrF₃N₃
Molecular Weight	316.08 g/mol
Synonyms	6-Bromo-4-amino-2-(trifluoromethyl)quinoline-3-carbonitrile; 4-Amino-6-bromo-2-trifluoromethylquinoline-3-carbonitrile; 2-(Trifluoromethyl)-4-amino-6-bromoquinoline-3-carbonitrile; 3-Cyano-4-amino-6-bromo-2-trifluoromethylquinoline; Quinoline-3-carbonitrile, 4-amino-6-bromo-2-(trifluoromethyl)-; 1209063-53-5; 4-Amino-6-bromo-2-(trifluoromethyl)-3-quinolinecarbonitrile
EINECS	Contact for details

Quality Control

Our 4-Amino-6-Bromo-2-(Trifluoromethyl)Quinoline-3-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards. Our quality commitment ensures reliable supply for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.