Description

(R)-1-(4-(Trifluoromethoxy)Phenyl)Ethanamine Hydrochloride is a high-purity chiral amine building block of significant importance in advanced organic synthesis. Its core value lies in providing a stereochemically defined scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require enantiomerically pure intermediates for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Agrochemical Synthesis: Used in the production of enantiomerically pure pesticides and herbicides, where specific stereochemistry can enhance efficacy and reduce environmental impact.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Research: A valuable building block in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries.
• Fine Chemical Production: Employed in the manufacture of other high-value, optically active specialty chemicals and flavors/fragrances intermediates.

Basic Information

Product Name	(R)-1-(4-(Trifluoromethoxy)Phenyl)Ethanamine Hydrochloride
CAS No.	1208989-29-0
Molecular Formula	C9H11F3NO•HCl
Molecular Weight	241.65 g/mol
Synonyms	(R)-1-[4-(Trifluoromethoxy)phenyl]ethylamine hydrochloride; (R)-α-Methyl-4-(trifluoromethoxy)benzylamine hydrochloride; (R)-1-(4-Trifluoromethoxyphenyl)ethan-1-amine hydrochloride; (R)-4-(Trifluoromethoxy)phenethylamine hydrochloride (common misnomer); (R)-TFAE-HCl; (R)-TFMPEA-HCl; (R)-1-(4-(Trifluoromethoxy)phenyl)ethanamine HCl; (R)-1-(4-(Trifluoromethoxy)phenyl)ethylammonium chloride
EINECS	Contact for details

Quality Control

Our (R)-1-(4-(Trifluoromethoxy)Phenyl)Ethanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high-purity standards required for pharmaceutical and advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.