Description

4-Amino-3-Chloro-8-Trifluoromethoxyquinoline is a high-value, multi-functional quinoline derivative that serves as a critical building block in advanced organic synthesis. Its unique trifluoromethoxy and chloro-amino substitution pattern makes it a versatile intermediate for developing novel active compounds. This product is primarily targeted at research and development teams in the pharmaceutical and agrochemical industries seeking to create new molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors, antimicrobials, and anti-cancer agents.
• Agrochemical Research: Used in developing advanced pesticides and herbicides, where the trifluoromethoxy group can improve lipophilicity and biological activity.
• Material Science: Building block for creating specialized organic ligands, dyes, and functional polymers.
• Chemical Synthesis: Versatile scaffold for further functionalization via reactions at the amino and chloro groups, enabling library synthesis for high-throughput screening.

Basic Information

Product Name	4-Amino-3-Chloro-8-Trifluoromethoxyquinoline
CAS No.	1208849-33-5
Molecular Formula	C11H7ClF3N2O
Molecular Weight	275.63 g/mol
Synonyms	3-Chloro-4-amino-8-(trifluoromethoxy)quinoline; 8-(Trifluoromethoxy)-3-chloroquinolin-4-amine; 4-Amino-3-chloro-8-(trifluoromethoxy)quinoline; Quinoline, 4-amino-3-chloro-8-(trifluoromethoxy)-; 4-Amino-3-chloro-8-trifluoromethoxyquinoline; CAS 1208849-33-5
EINECS	Contact for details

Quality Control

Our 4-Amino-3-Chloro-8-Trifluoromethoxyquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be light-sensitive and hygroscopic; keep the container tightly sealed when not in use to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.