Description

4-Bromo-3-Chloro-8-Trifluoromethoxyquinoline is a high-value, multi-functional halogenated quinoline derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its molecular architecture, featuring bromo, chloro, and trifluoromethoxy substituents, makes it an indispensable building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antimicrobial agents, and other biologically active heterocycles.
• Agrochemical Research: Used in the development of new generation pesticides, herbicides, and fungicides, where the quinoline core and halogen atoms contribute to bioactivity and environmental stability.
• Material Science: Serves as a monomer or functional unit in the creation of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters or charge-transport layers.
• Chemical Synthesis: Versatile scaffold for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and further functionalization due to the reactive bromo and chloro groups.
• Ligand and Catalyst Development: Utilized to create novel chelating ligands for metal catalysts used in asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	4-Bromo-3-Chloro-8-Trifluoromethoxyquinoline
CAS No.	1208755-84-3
Molecular Formula	C₁₁H₄BrClF₃NO
Molecular Weight	330.51 g/mol
Synonyms	4-Bromo-3-chloro-8-(trifluoromethoxy)quinoline; 8-Trifluoromethoxy-4-bromo-3-chloroquinoline; Quinoline, 4-bromo-3-chloro-8-(trifluoromethoxy)-; 4-Bromo-3-chloro-8-trifluoromethoxy-quinoline; 4-Br-3-Cl-8-OCF3-Quinoline
EINECS	Contact for details

Quality Control

Our production of 4-Bromo-3-Chloro-8-Trifluoromethoxyquinoline adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including HPLC, GC-MS, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.