Description

n-Acetyl-2-o-Propargyl-A-Neuraminic Acid is a chemically modified derivative of sialic acid, featuring a strategically introduced propargyl group. This compound is a critical intermediate and building block in chemical biology and pharmaceutical research, enabling advanced applications through click chemistry and bioconjugation techniques. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers focused on glycobiology, antiviral drug discovery, and the synthesis of novel diagnostic probes.

Application

• Chemical Biology Research: Key intermediate for synthesizing sialic acid analogs to study glycan-mediated biological processes.
• Antiviral Drug Development: Serves as a precursor for creating neuraminidase inhibitors targeting influenza and other viruses.
• Bioconjugation & Probe Synthesis: The propargyl group facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling biomolecules.
• Glycoprotein & Glycolipid Engineering: Used to modify cell surface glycans for functional studies and therapeutic applications.
• Diagnostic Reagent Manufacturing: Employed in the production of high-specificity assay components and diagnostic kits.
• Academic & Industrial R&D: Fundamental building block for exploring new synthetic pathways in carbohydrate chemistry.

Basic Information

Product Name	n-Acetyl-2-o-Propargyl-A-Neuraminic Acid
CAS No.	1208376-36-6
Molecular Formula	C16H23NO9
Molecular Weight	373.36 g/mol
Synonyms	5-Acetamido-3,5-dideoxy-2-O-(prop-2-yn-1-yl)-D-glycero-D-galacto-non-2-ulopyranosonic acid; 2-O-Propargyl-N-acetylneuraminic acid; Propargyl-modified Sialic Acid; Sialic Acid Propargyl Ether; NANA-Propargyl derivative; Click chemistry sialic acid; CAS 1208376-36-6
EINECS	Contact for details

Quality Control

Our n-Acetyl-2-o-Propargyl-A-Neuraminic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.