Description

Benzene, 1-Bromo-3-Fluoro-5-(Methylsulfonyl) is a high-value, multi-functional aromatic building block designed for advanced synthetic chemistry. This compound matters because its unique combination of bromo, fluoro, and methylsulfonyl substituents offers versatile reactivity for cross-coupling, nucleophilic substitution, and as a key intermediate in complex molecule construction. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized monomers and ligands in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated fluorine and electron-withdrawing methylsulfonyl group facilitate efficient substitution reactions with various nucleophiles.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes, enzyme inhibitors, and activity-based protein profiling (ABPP) reagents.

Basic Information

Product Name	Benzene, 1-Bromo-3-Fluoro-5-(Methylsulfonyl)
CAS No.	1207970-78-2
Molecular Formula	C7H6BrFO2S
Molecular Weight	253.09 g/mol
Synonyms	1-Bromo-3-fluoro-5-(methylsulfonyl)benzene; 3-Bromo-5-fluorophenyl methyl sulfone; 5-Bromo-3-fluorophenyl methyl sulfone; Methyl 3-bromo-5-fluorophenyl sulfone; 1-Bromo-3-fluoro-5-methanesulfonylbenzene; 3-Fluoro-5-bromophenyl methyl sulfone; (3-Bromo-5-fluorophenyl)(methyl)sulfone
EINECS	Contact for details

Quality Control

Our Benzene, 1-Bromo-3-Fluoro-5-(Methylsulfonyl) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications in cGMP and non-GMP environments, ensuring reliable supply and batch-to-batch reproducibility for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.