Description

Methyl 2-Amino-3-(1-Methyl-1H-Imidazol-5-Yl)Propanoate Hydrochloride is a high-purity, non-natural amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate, valued for its unique imidazole-containing side chain which is instrumental in modulating biological activity and physicochemical properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel drug candidates, particularly in areas targeting enzyme inhibition and receptor modulation.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting neurological and metabolic disorders.
• Peptidomimetics Research: Used in the design and construction of peptidomimetic compounds, where the imidazole moiety can mimic histidine or act as a metal-binding ligand.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore new chemical entities with potential therapeutic effects.
• Bioconjugation: The ester and amine functionalities provide handles for conjugation to other molecules, peptides, or solid supports in probe and prodrug development.
• Chemical Biology Tool: Serves as a precursor for synthesizing labeled compounds or molecular probes used in biochemical assays and imaging studies.
• Process Chemistry Development: Used in scaling up synthetic routes for potential drug candidates during preclinical and early-phase development.

Basic Information

Product Name	Methyl 2-Amino-3-(1-Methyl-1H-Imidazol-5-Yl)Propanoate Hydrochloride
CAS No.	1207887-43-1
Molecular Formula	C9H15N3O2 • HCl
Molecular Weight	233.70 g/mol (Free base: 197.24 g/mol)
Synonyms	L-Histidine methyl ester analog hydrochloride; 1-Methyl-1H-imidazole-5-propanoic acid, 2-amino-α-methyl ester, hydrochloride; Methyl 2-amino-3-(1-methylimidazol-5-yl)propionate HCl; (S)-Methyl 2-amino-3-(1-methyl-1H-imidazol-5-yl)propanoate hydrochloride; 1207887-43-1; Methyl 3-(1-methyl-1H-imidazol-5-yl)-2-aminopropanoate hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl 2-Amino-3-(1-Methyl-1H-Imidazol-5-Yl)Propanoate Hydrochloride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and lot-to-lot consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.