Description

3-Bromo-4-Chloro-8-Trifluoromethylquinoline is a high-value, multi-functional halogenated quinoline derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique trifluoromethyl and halogen substitution pattern makes it an indispensable building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel agrochemicals, pharmaceuticals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the quinoline scaffold and fluorine atoms contribute to bioactivity and environmental stability.
• Material Science: Serves as a monomer or functional additive in the creation of organic semiconductors, liquid crystals, and advanced polymers requiring specific electronic characteristics.
• Chemical Synthesis: Acts as a versatile reagent for metal-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex quinoline motifs into larger molecular architectures.
• Fluorine Chemistry: An important substrate for studying structure-activity relationships (SAR) in fluorinated compounds due to the presence of the metabolically stable trifluoromethyl group.

Basic Information

Item	Details
Product Name	3-Bromo-4-Chloro-8-Trifluoromethylquinoline
CAS No.	1204812-14-5
Molecular Formula	C₁₀H₄BrClF₃N
Molecular Weight	310.50 g/mol
Synonyms	8-Trifluoromethyl-3-bromo-4-chloroquinoline; 3-Bromo-4-chloro-8-(trifluoromethyl)quinoline; 4-Chloro-3-bromo-8-trifluoromethylquinoline; Quinoline, 3-bromo-4-chloro-8-(trifluoromethyl)-; 1204812-14-5; BCTQ
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-4-Chloro-8-Trifluoromethylquinoline is manufactured and tested under a strict quality management system. We guarantee high-purity material suitable for demanding research and scale-up applications. Comprehensive analytical testing, including HPLC, GC, NMR, and MS, is performed to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (HPLC)	≥ 99.0% (High-Purity Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.