Description

4-((4-Nitrobenzylamino)Methyl)Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine core and nitrobenzylamino functional group. This compound is essential for research and development in medicinal chemistry, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in areas requiring complex amine derivatives.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting neurological and cardiovascular disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: Serves as a building block for compounds designed to inhibit specific enzymes, such as proteases involved in disease pathways.
• Ligand Synthesis for Receptor Studies: Employed in the creation of ligands for pharmacological characterization of G-protein coupled receptors (GPCRs) and other targets.
• Fine Chemical Synthesis: Used in multi-step organic synthesis to introduce protected piperidine and aromatic amine functionalities into complex molecules.
• Chemical Biology Probes: Acts as a component in the development of chemical probes for studying biological processes and protein function.

Basic Information

Product Name	4-((4-Nitrobenzylamino)Methyl)Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1204811-89-1
Molecular Formula	C18H27N3O4
Molecular Weight	349.43 g/mol
Synonyms	1-Boc-4-((4-nitrobenzylamino)methyl)piperidine; tert-Butyl 4-((4-nitrobenzylamino)methyl)piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-((4-nitrobenzylamino)methyl)piperidine; 4-[(4-Nitrobenzylamino)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; N-[(1-Boc-4-piperidinyl)methyl]-4-nitrobenzylamine; 4-((4-Nitrobenzylamino)methyl)piperidine-1-carboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 4-((4-Nitrobenzylamino)Methyl)Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliable consistency and traceability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.