Description

3-Bromo-4-Chloro-5,8-Difluoroquinoline is a high-value, multi-halogenated quinoline derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating new compounds with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel quinolone-based antibiotics, kinase inhibitors, and other therapeutic agents.
• Agrochemical Research: Used in developing new candidates for fungicides and herbicides, leveraging the bioactivity of the halogenated quinoline core.
• Material Science: Serves as a precursor for organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Synthesis: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex quinoline scaffolds into larger molecules.
• Academic & Contract Research: Employed in university and CRO laboratories for medicinal chemistry programs and methodological studies.

Basic Information

Product Name	3-Bromo-4-Chloro-5,8-Difluoroquinoline
CAS No.	1204811-16-4
Molecular Formula	C9H3BrClF2N
Molecular Weight	278.48 g/mol
Synonyms	3-Bromo-4-chloro-5,8-difluoroquinoline; 5,8-Difluoro-3-bromo-4-chloroquinoline; Quinoline, 3-bromo-4-chloro-5,8-difluoro-; 1204811-16-4; 3-Bromo-4-chloro-5,8-difluoro-quinoline
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Chloro-5,8-Difluoroquinoline is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting the exact specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.