Description

3-Bromo-4-Chloro-6-Trifluoromethylquinoline is a high-value, multi-halogenated quinoline derivative that serves as a critical building block in advanced organic synthesis. Its unique molecular architecture, featuring bromo, chloro, and trifluoromethyl substituents, makes it an indispensable intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically active heterocycles.
• Agrochemical Research: Used to develop new generations of herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the halogen and trifluoromethyl groups.
• Material Science: Building block for creating specialized organic electronic materials, such as charge-transport layers or light-emitting components, due to the quinoline core's electronic properties.
• Chemical Synthesis: Versatile scaffold for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) enabled by the reactive bromo substituent.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel nitrogen-containing ligands used in homogeneous catalysis.

Basic Information

Product Name	3-Bromo-4-Chloro-6-Trifluoromethylquinoline
CAS No.	1204810-99-0
Molecular Formula	C10H4BrClF3N
Molecular Weight	310.50 g/mol
Synonyms	3-Bromo-4-chloro-6-(trifluoromethyl)quinoline; 6-Trifluoromethyl-3-bromo-4-chloroquinoline; Quinoline, 3-bromo-4-chloro-6-(trifluoromethyl)-; 1204810-99-0; 3-Br-4-Cl-6-CF3-Quinoline
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-4-Chloro-6-Trifluoromethylquinoline is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data for purity, identity, and impurity profiles. Our standard quality commitment ensures the material meets the high-purity requirements essential for research and scale-up applications. Specifications and analytical methods (including HPLC, GC, NMR, and MS) are available for customer review.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.