Description

3-Chloro-6,8-Difluoro-4-Hydroxyquinoline is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique halogenated quinoline structure makes it a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel quinolone and fluoroquinolone antibiotic candidates, leveraging its halogenated scaffold for structure-activity relationship (SAR) studies.
• Agrochemical Research: Serves as a core building block in developing new-generation fungicides and herbicides, where the difluoro and chloro substituents enhance biological activity and environmental stability.
• Material Science Precursor: Used in the research and development of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology Probe: Employed as a scaffold for creating fluorescent tags or enzyme inhibitors in biochemical and medicinal chemistry research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP or research-grade conditions.

Basic Information

Product Name	3-Chloro-6,8-Difluoro-4-Hydroxyquinoline
CAS No.	1204810-83-2
Molecular Formula	C9H4ClF2NO
Molecular Weight	215.59 g/mol
Synonyms	4-Hydroxy-3-chloro-6,8-difluoroquinoline; 6,8-Difluoro-3-chloro-4-hydroxyquinoline; 3-Chloro-6,8-difluoroquinolin-4-ol; 4-Quinolinol, 3-chloro-6,8-difluoro-; 1204810-83-2; 3-Cl-6,8-F2-4-OH-Q
EINECS	Contact for details

Quality Control

Our 3-Chloro-6,8-Difluoro-4-Hydroxyquinoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications. Custom purity grades, including >98% and >99%, are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.