Description

3-Chloro-5,8-Difluoro-4-Hydroxyquinoline is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique halogenated quinoline structure makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antibacterial and antiviral agents, leveraging the bioactive quinoline scaffold.
• Agrochemical Synthesis: Used in the development of next-generation fungicides and herbicides, where the difluoro and chloro substituents enhance biological activity and environmental stability.
• Material Science Research: Serves as a building block for creating organic ligands in catalytic systems or functional materials.
• Chemical Biology Probes: Utilized in medicinal chemistry to develop fluorescent probes or enzyme inhibitors for biological target studies.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis projects requiring complex, halogenated heterocycles.

Basic Information

Product Name	3-Chloro-5,8-Difluoro-4-Hydroxyquinoline
CAS No.	1204810-44-5
Molecular Formula	C9H4ClF2NO
Molecular Weight	215.59 g/mol
Synonyms	4-Hydroxy-3-chloro-5,8-difluoroquinoline; 5,8-Difluoro-3-chloro-4-hydroxyquinoline; 3-Chloro-5,8-difluoroquinolin-4-ol; 4-Quinolinol, 3-chloro-5,8-difluoro-; Quinoline, 3-chloro-5,8-difluoro-4-hydroxy-; CAS 1204810-44-5
EINECS	Contact for details

Quality Control

Our 3-Chloro-5,8-Difluoro-4-Hydroxyquinoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.