Description

6,8-Difluoro-4-Hydrazino-2-Methylquinoline Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoroquinoline scaffold. This compound matters as a critical building block in the synthesis of novel, potent drug candidates, particularly in the development of kinase inhibitors and antibacterial agents. Pharmaceutical R&D laboratories and fine chemical manufacturers require this material for its role in constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors targeting various oncology and inflammatory pathways.
• Antibacterial Agent Research: Used as a core scaffold for developing next-generation fluoroquinolone analogs with improved efficacy.
• Chemical Biology: Serves as a versatile handle for bioconjugation and probe development due to the reactive hydrazino group.
• Agrochemical Synthesis: Employed in research for creating new active ingredients with fluorinated quinoline structures.
• Material Science Research: Investigated as a ligand or building block for metal-organic frameworks (MOFs) and functional materials.

Basic Information

Product Name	6,8-Difluoro-4-Hydrazino-2-Methylquinoline Hydrochloride
CAS No.	1204810-35-4
Molecular Formula	C₁₁H₁₀F₂N₃·HCl
Molecular Weight	261.67 g/mol (Free base: 225.21 g/mol)
Synonyms	4-Hydrazino-6,8-difluoro-2-methylquinoline Hydrochloride; 6,8-Difluoro-2-methyl-4-quinolinehydrazine Hydrochloride; 2-Methyl-6,8-difluoro-4-hydrazinylquinoline Hydrochloride; 1204810-35-4; 4-Hydrazinyl-6,8-difluoro-2-methylquinoline HCl; 6,8-Difluoro-2-methylquinolin-4-ylhydrazine Hydrochloride
EINECS	Contact for details

Quality Control

Our 6,8-Difluoro-4-Hydrazino-2-Methylquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, the container should be kept under an inert atmosphere (e.g., nitrogen or argon) after opening and protected from moisture. Keep away from strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.