Description

3-Chloro-4-Hydroxy-8-Trifluoromethylquinoline is a high-value, multi-functional heterocyclic building block characterized by its unique trifluoromethyl and chloro-hydroxy substitution pattern. This compound matters for its role as a critical synthetic intermediate in the development of advanced pharmaceuticals and agrochemicals, where its structure imparts desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in antimicrobial, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Building block for developing next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the quinoline core.
• Material Science Research: Used in the creation of organic semiconductors, ligands for catalysis, and advanced polymers due to its electron-deficient aromatic system.
• Chemical Biology & Proteomics: Serves as a scaffold or tagging agent in the design of molecular probes and enzyme inhibitors for biochemical research.
• Dye & Pigment Intermediate: Potential starting material for synthesizing specialized fluorinated quinoline-based dyes and optical brighteners.

Basic Information

Product Name	3-Chloro-4-Hydroxy-8-Trifluoromethylquinoline
CAS No.	1204810-22-9
Molecular Formula	C10H5ClF3NO
Molecular Weight	247.60 g/mol
Synonyms	8-Trifluoromethyl-3-chloro-4-quinolinol; 3-Chloro-4-hydroxy-8-(trifluoromethyl)quinoline; 4-Hydroxy-3-chloro-8-trifluoromethylquinoline; 3-Chloro-8-trifluoromethylquinolin-4-ol; Quinoline, 3-chloro-4-hydroxy-8-(trifluoromethyl)-; 1204810-22-9; 8-(Trifluoromethyl)-3-chloroquinolin-4-ol
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Hydroxy-8-Trifluoromethylquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure compliance with exacting R&D and production standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.