Description

3-[[[3,5-Bis(Trifluoromethyl)Phenyl]Methyl]Amino]-4-[[(8α,9S)-10,11-Dihydro-6'-Methoxycinchonan-9-Yl]Amino]-3-Cyclobutene-1,2-Dione is a sophisticated, high-value organic compound featuring a complex molecular architecture derived from a cinchona alkaloid core and a trifluoromethylated phenyl group. This compound is of significant interest for its potential as a highly selective chiral ligand or catalyst in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily targeted at research institutions, pharmaceutical R&D laboratories, and advanced chemical synthesis facilities engaged in developing novel therapeutic agents and catalytic processes.

Application

• Asymmetric Catalysis: Serving as a chiral ligand or organocatalyst for enantioselective carbon-carbon and carbon-heteroatom bond-forming reactions.
• Pharmaceutical Intermediate: A key building block in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or anti-malarial targets.
• Methodology Development: Used in academic and industrial research to develop new synthetic methodologies and catalytic cycles.
• Chiral Resolution: Potential application in the separation of racemic mixtures due to its inherent chirality and complexing ability.
• Chemical Biology Probe: Utilized in biochemical research as a tool compound to study enzyme mechanisms or protein-ligand interactions.

Basic Information

Product Name	3-[[[3,5-Bis(Trifluoromethyl)Phenyl]Methyl]Amino]-4-[[(8α,9S)-10,11-Dihydro-6'-Methoxycinchonan-9-Yl]Amino]-3-Cyclobutene-1,2-Dione
CAS No.	1204591-53-6
Molecular Formula	C₃₅H₂₈F₆N₄O₃
Molecular Weight	666.62 g/mol
Synonyms	3-(((3,5-Bis(trifluoromethyl)benzyl)amino)-4-(((8α,9S)-10,11-dihydro-6'-methoxycinchonan-9-yl)amino)cyclobut-3-ene-1,2-dione; Cinchona Alkaloid-Derived Cyclobutenedione; (8α,9S)-9-((4-(((3,5-Bis(trifluoromethyl)benzyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)-10,11-dihydro-6'-methoxycinchonan; 1204591-53-6; Cinchonidine-based trifluoromethyl catalyst; Chiral cyclobutenedione ligand.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high purity essential for research and development. Identity and purity are confirmed via advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.