Description

2-(6-Chloropyridin-3-Yl)-2,2-Difluoroethanamine is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoroethylamine-substituted pyridine core. This compound is of significant commercial importance as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the agrochemical and pharmaceutical research sectors. It is primarily sought after by R&D chemists and process development scientists working on innovative crop protection agents and therapeutic compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) and anti-infective therapies.
• Agrochemical Synthesis: Serves as a crucial precursor in the manufacture of next-generation insecticides and pesticides, leveraging the bioactivity of the chloropyridine moiety.
• Chemical Research & Development: Used in academic and industrial R&D labs for exploring new chemical entities and reaction pathways involving fluorinated amines.
• Ligand and Catalyst Preparation: The amine functionality makes it suitable for the synthesis of specialized ligands for metal catalysis or as a building block for functional materials.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules on a commercial scale.

Basic Information

Product Name	2-(6-Chloropyridin-3-Yl)-2,2-Difluoroethanamine
CAS No.	1204235-05-1
Molecular Formula	C7H7ClF2N2
Molecular Weight	192.59 g/mol
Synonyms	2,2-Difluoro-2-(6-chloro-3-pyridinyl)ethanamine; 2-(6-Chloro-3-pyridinyl)-2,2-difluoroethanamine; 2,2-Difluoro-2-(6-chloropyridin-3-yl)ethanamine; 6-Chloro-3-(2,2-difluoroethylamino)pyridine; 1204235-05-1; 2-(6-Chloro-3-pyridyl)-2,2-difluoroethylamine; 2,2-Difluoro-1-(6-chloropyridin-3-yl)ethan-1-amine
EINECS	Contact for details

Quality Control

Our 2-(6-Chloropyridin-3-Yl)-2,2-Difluoroethanamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP standards where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.