Description

2-(6-Chloropyridin-2-Yl)-2,2-Difluoroethan-1-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoroethylamine-substituted chloropyridine scaffold. This compound is of significant commercial importance for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the agrochemical and pharmaceutical sectors. It is primarily sought after by R&D chemists and process development scientists working on innovative crop protection agents and therapeutic compounds, where its specific halogen and fluorine pattern enables precise molecular modifications.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Serves as a crucial precursor in the manufacture of next-generation insecticides and herbicides, leveraging the bioactivity of the chloropyridine moiety.
• Chemical Research & Development: Used in academic and industrial R&D for exploring new chemical entities and structure-activity relationships (SAR).
• Ligand and Catalyst Preparation: Utilized in the synthesis of specialized ligands for metal-catalyzed coupling reactions due to its nitrogen-containing heterocycle.
• Fluorinated Building Block: The difluoroethylamine group makes it a valuable fragment for introducing fluorine atoms to enhance metabolic stability and bioavailability in target molecules.

Basic Information

Product Name	2-(6-Chloropyridin-2-Yl)-2,2-Difluoroethan-1-Amine
CAS No.	1204234-55-8
Molecular Formula	C7H7ClF2N2
Molecular Weight	192.59 g/mol
Synonyms	2,2-Difluoro-2-(6-chloro-2-pyridinyl)ethanamine; 2-(6-Chloro-2-pyridinyl)-2,2-difluoroethanamine; 2-(6-Chloropyridin-2-yl)-2,2-difluoroethanamine; 6-Chloro-2-(2,2-difluoroethylamino)pyridine; 2-Amino-1-(6-chloropyridin-2-yl)-1,1-difluoroethane; 1-(6-Chloro-2-pyridinyl)-2,2-difluoroethylamine; 2,2-Difluoro-1-(6-chloro-2-pyridinyl)ethanamine
EINECS	Contact for details

Quality Control

Our 2-(6-Chloropyridin-2-Yl)-2,2-Difluoroethan-1-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards where applicable, ensuring reliability for your most critical synthesis stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.