Description

8-Bromo-6-Fluoroquinazolin-4(3H)-One is a high-purity, advanced pharmaceutical intermediate belonging to the quinazolinone class of heterocyclic compounds. Its core value lies in its versatile chemical structure, which serves as a critical building block for the synthesis of targeted therapeutic agents. This compound is essential for research and development chemists in the pharmaceutical and biotechnology industries, particularly those focused on oncology and kinase inhibitor discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drugs, especially kinase inhibitors for cancer therapy.
• Chemical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold in multi-step synthetic routes for complex API manufacturing.
• Biochemical Research: Employed as a tool compound in biochemical assays to study enzyme inhibition and cellular signaling pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	8-Bromo-6-Fluoroquinazolin-4(3H)-One
CAS No.	1204101-90-5
Molecular Formula	C8H4BrFN2O
Molecular Weight	243.04 g/mol
Synonyms	8-Bromo-6-fluoro-3,4-dihydroquinazolin-4-one; 8-Bromo-6-fluoro-4(3H)-quinazolinone; 6-Fluoro-8-bromoquinazolin-4(3H)-one; 4(3H)-Quinazolinone, 8-bromo-6-fluoro-; 1204101-90-5; 8-Br-6-F-quinazolin-4-one
EINECS	Contact for details

Quality Control

Our 8-Bromo-6-Fluoroquinazolin-4(3H)-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to verify identity and purity. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.