Description

1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylicacid,1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- is a high-purity, advanced pharmaceutical intermediate featuring a protected carboxylic acid group and a SEM (2-(trimethylsilyl)ethoxymethyl) protecting group on the nitrogen. This compound is critical for enabling complex synthetic routes in medicinal chemistry by providing selective reactivity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up API synthesis under GMP conditions.
• Organic Synthesis Reagent: Employed in academic and industrial labs for constructing fused heterocyclic systems common in agrochemicals and materials science.
• Custom Synthesis Projects: Basis for producing tailored derivatives and analogs for client-specific research programs.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylicacid,1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-
CAS No.	1203955-66-1
Molecular Formula	C14H20N2O3Si
Molecular Weight	292.41 g/mol
Synonyms	1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; 1-SEM-7-Azaindole-3-carboxylic Acid; 1-[[2-(Trimethylsilyl)ethoxy]methyl]-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, 1-[[2-(trimethylsilyl)ethoxy]methyl]-; 5-Carboxy-1-SEM-7-azaindole; 7-Azaindole-3-carboxylic acid, 1-SEM-protected; SEM-7-AzaIndole-3-Carboxylic Acid
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylicacid,1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.