Description

4,4-Dimethyl-6-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a complex tetrahydroisoquinoline scaffold. This compound matters for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily needed by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those with tetrahydroisoquinoline-based structures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs in drug discovery.
• CNS Drug Development: Serves as a building block for potential therapeutics targeting neurological and psychiatric conditions.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for API manufacturing.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for biological target identification and validation.
• Custom Synthesis: A starting material for the contract manufacturing of bespoke, high-value fine chemicals.

Basic Information

Product Name	4,4-Dimethyl-6-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride
CAS No.	1203686-10-5
Molecular Formula	C12H14F3N•HCl
Molecular Weight	265.70 g/mol
Synonyms	6-(Trifluoromethyl)-4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; 4,4-Dimethyl-6-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline HCl; 1,2,3,4-Tetrahydro-4,4-dimethyl-6-(trifluoromethyl)isoquinoline hydrochloride; 4,4-Dimethyl-6-(trifluoromethyl)-3,4-dihydro-1H-isoquinoline hydrochloride; 6-(Trifluoromethyl)-4,4-dimethyl-3,4-dihydroisoquinoline hydrochloride
EINECS	Contact for details

Quality Control

Our 4,4-Dimethyl-6-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.